Krux AI
RFP intelligence for pharma contract manufacturers.
Krux reads every incoming RFP, scores it against what your plant can actually do, writes the response, and prices it. Every answer is cited back to your batch records and to the senior operators who know how to win.
25h to 2h senior time per RFP91% cost-prediction accuracy70+ yrs advisor expertise codified
● Krux flagged · BX-3142 draft
“Standard HBTU/HOBt activation will deliver greater than 99% coupling efficiency for all 31 residues using TCG’s validated cGMP coupling protocol.”
Why Krux flagged it
BX-3142 has Aib at positions 2, 16, 22. HBTU/HOBt alone gives 70–85% on Aib. Two top-10 CDMOs lost peptide batches on this exact issue (kb-a-2). Switch to dual-protocol with pre-formed Fmoc-Aib-OPfp esters.
JA
J. Adams · 30yr Boehringer Ingelheim
codified Aib coupling protocol · 2026-03-14
The problem
Every pharma CDMO is one retirement away from losing the people who know how to win RFPs.
20–30 hrs
of senior time burned per RFP, on a 20–25% win rate.
50,000+
unfilled US biomanufacturing roles. Senior chemists are retiring faster than they're replaced.
Zero systems
of record. Decision logic lives in 5 senior heads, scattered across 40 emails per RFP.
How Krux wins RFPs
Two layers of source data. Every claim cited.
Every answer Krux gives points back to one of two places: your own manufacturing data, or the codified expertise of senior operators. No hallucinations. Every claim cites its source.
Layer A. Customer data
412 cGMP batch records. Every reactor. Every inspection.
- · Batch records & yield curves, 2018→
- · Reactor train validation envelopes
- · FDA / EMA inspection histories
- · 9-yr sponsor + bid outcome log
- · Live plant capacity feed
Layer B. Expert Knowledge
70+ years of pharma decision logic, captured 1-on-1.
- · J. Adams · 30yr Boehringer Ingelheim VP Process Chem
- · C. Reyes · 40yr Merck Sr. Director CMC
- · Codified protocols, failure modes, sponsor patterns
- · Re-verified quarterly by the source
01
Ingest
Drop in any inbound RFP. Email, PDF, or paste. Krux pulls out the molecule, scope, timeline, and budget in 2.4 sec.
02
Score & flag
Capability fit, win probability, predicted margin. Every overcommit (cryogenic envelope, Aib coupling, EMA Q3D) gets caught before submission.
03
Draft & price
Cited paragraph-by-paragraph from your KB. Pricing defended against historical bid bands. 25 hrs of senior time → 2 hrs of review.
Founding advisors
70 years of process chemistry, codified directly into the product.
JA
Joe Adams
30 yrs · Boehringer Ingelheim · former VP Process Chem
“We lost a 14 kg lot at BI in 2017 because someone skipped post-Aib capping. That kind of one-line constraint is exactly what Krux now flags before a draft goes out.”
See codified protocols →
CR
Chris Reyes
40 yrs · Merck · former Sr. Director CMC
“The decision logic in this industry has been trapped in heads and emails for 30 years. Krux is the first system I've seen that captures it without dumbing it down.”
See codified protocols →
Where this goes
We start with the RFP, because it’s where every CDMO bleeds the most senior time. The longer arc is bigger: a Company Brain for pharma manufacturing, where every operator’s decision logic is captured before they retire and made addressable across the supply chain.
Phase 1 (live today): RFP intelligence · Phase 2: full Knowledge Base · Phase 3: cross-tenant data layer